Everything about Ankyrin totally explained
.
| image = Ankyrin R membrane-binding domain 1N11.png
| width = 250
| HGNCid = 492
| Symbol =
ANK1
| AltSymbols = ANK
| EntrezGene = 286
| OMIM = 182900
| RefSeq = NM_000037
| UniProt = P16157
| PDB =
| ECnumber =
| Chromosome = 8
| Arm = p
| Band = 21.1
| LocusSupplementaryData = -11.2
}}
Ankyrins are a family of proteins that mediates the attachment of
integral membrane proteins to the
cytoskeleton.
Ankyrin 1, was first discovered in the
erythrocytes but also later found to be expressed in the brain and muscles. In erythrocytes, Ankyrin 1 links membrane receptor
CD44 to
inositol triphosphate and the cytoskeleton.
Ankyrin contains three functional
domains: a conserved
N-terminal ankyrin repeat domain (ARD) consisting of 22–24 tandem repeats of 33 amino acids, a
spectrin binding domain and a variably sized
C-terminal regulatory
domain. A single ankyrin repeat consists of a beta strand followed by two
alpha helices and then another beta strand. The beta strands on adjacent ankyrin repeats combine to form a short antiparallel
beta sheet.
Ankyrin was discovered by Dr. G. Vann Bennett (M.D., PhD.) in 1979.
Further Information
Get more info on 'Ankyrin'.
|
External Link Exchanges
Do you know how hard it is to get a link from a large encyclopaedia? Well we're different and will prove it. To get a link from us just add the following HTML to your site on a relevant page:
<a href="http://ankyrin.totallyexplained.com">Ankyrin Totally Explained</a>
Then simply click through this link from your web page. Our crawlers will verify your link, extract the title of your web page and instantly add a link back to it. If you like you can remove the words Totally Explained and embed the link in article text.
As long as your link remains in place, we'll keep our link to you right here. Please play fair - our crawlers are watching. Your site must be closely related to this one's topic. Any kind of spamming, dubious practises or removing the link will result in your link from us being dropped and, potentially, your whole site being banned. |
